ea0014p346 | (1) | ECE2007
Gozu Hulya
, Mueller Sandra
, Bircan Rifat
, Krohn Knut
, Sargin Mehmet
, Sargin Haluk
, Gezen Cem
, Erginer Turgay
, Karadayi Nimet
, Paschke Ralf
Constitutive activation of the cAMP pathway by activating TSHR mutation stimulates both thyrocyte proliferation and function. Thus they lead to formation of toxic thyroid nodules (TTNs) and ultimately hyperthyroidism. The in vitro activity of the various TSH-receptor mutation varies from 27 fold cAMP increase over the wild type TSH receptor. One previous study invrestigated a possible genotype to phenotype relation in TTNs with somatic TSHR mutation with a negativ...